Fibronectin fragments upregulate insulin-like growth factor binding proteins in chondrocytes
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چکیده
منابع مشابه
Binding of mutants of human insulin-like growth factor II to insulin-like growth factor binding proteins 1-6.
A family of six specific insulin-like growth factor binding proteins (IGFBPs) modulates the biological actions of the insulin-like growth factors, IGF-I and IGF-II. In the present study, we determined the binding affinity of purified human IGFBPs 1-6 for recombinant human IGF-II mutants whose binding to IGF-I, IGF-II/mannose 6-phosphate, and insulin receptors was previously reported (Sakano, K....
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PURPOSE Müller cells are consistently identified in diabetic fibrocontractive ocular tissues and, in response to insulin-like growth factor I, generate tractional forces of the type that cause retinal detachment. Recent studies suggest that diabetes-associated increases in vitreous insulin-like growth factor activity cannot be attributed to simple increases in concentration alone, suggesting th...
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The last decade has been characterized by a major investigative thrust into the physiology of two unique but ubiquitous peptides, insulin-like growth factor (IGF)-I and IGF-II. The regulatory systems that control the tissue bioactivity of the IGFs have been delineated, and subcellular signaling mechanisms have been clarified. Clearly, both tissue and circulating growth factor concentrations are...
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The insulin-like growth factor-binding proteins (IGFBPs) represent a family of conserved proteins that share the ability to bind the insulin-like growth factors, IGF-I and IGF-II, with affinities comparable to their respective receptors. Unlike the transmembrane IGF receptors, the IGFBPs are secreted proteins. Although many of the IGFBPs are able to interact with cell surface membranes, there i...
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ژورنال
عنوان ژورنال: Osteoarthritis and Cartilage
سال: 2002
ISSN: 1063-4584
DOI: 10.1053/joca.2002.0808